Stefano Comai Selected Research

Kynurenine

1/2024	Dysfunction in endocannabinoids, palmitoylethanolamide, and degradation of tryptophan into kynurenine in individuals with depressive symptoms.
12/2023	The kynurenine pathway in treatment-resistant schizophrenia at the crossroads between pathophysiology and pharmacotherapy.
9/2023	Importance of the dysregulation of the kynurenine pathway on cognition in schizophrenia: a systematic review of clinical studies.
11/2022	Investigation of Genetic Variants Associated with Tryptophan Metabolite Levels via Serotonin and Kynurenine Pathways in Patients with Bipolar Disorder.
4/2022	Is Poor Lithium Response in Individuals with Bipolar Disorder Associated with Increased Degradation of Tryptophan along the Kynurenine Pathway? Results of an Exploratory Study.
1/2022	Investigation of the Relationship among Cortisol, Pro-inflammatory Cytokines, and the Degradation of Tryptophan into Kynurenine in Patients with Major Depression and Suicidal Behavior.
1/2022	Selective association of cytokine levels and kynurenine/tryptophan ratio with alterations in white matter microstructure in bipolar but not in unipolar depression.
11/2021	Tryptophan Metabolites, Cytokines, and Fatty Acid Binding Protein 2 in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
10/2020	Prenatal IL-6 levels and activation of the tryptophan to kynurenine pathway are associated with depressive but not anxiety symptoms across the perinatal and the post-partum period in a low-risk sample.
12/2019	Grey and white matter structure associates with the activation of the tryptophan to kynurenine pathway in bipolar disorder.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Stefano Comai Research Topics

Disease

7	Bipolar Disorder (Manic Depressive Psychosis) 12/2023 - 12/2019
6	Neuralgia (Stump Neuralgia) 01/2022 - 02/2015
6	Pain (Aches) 01/2022 - 01/2014
5	Inflammation (Inflammations) 01/2024 - 10/2020
5	Mood Disorders (Mood Disorder) 04/2023 - 01/2014
5	Depressive Disorder (Melancholia) 01/2022 - 01/2015
5	Sleep Wake Disorders 10/2020 - 12/2011
4	Mental Disorders (Mental Disorder) 05/2024 - 01/2011
3	Personality Disorders (Personality Disorder) 11/2023 - 01/2018
3	Sleep Initiation and Maintenance Disorders (Insomnia) 11/2023 - 01/2014
3	Infections 11/2021 - 03/2007
3	Psychotic Disorders (Schizoaffective Disorder) 10/2020 - 01/2014
3	Substance-Related Disorders (Drug Abuse) 01/2019 - 10/2016
2	Treatment-Resistant Depressive Disorder 11/2023 - 01/2022
2	Major Depressive Disorder (Major Depressive Disorders) 10/2023 - 01/2022
2	Chronic Pain 01/2022 - 10/2015
2	Alcoholism (Alcohol Abuse) 11/2021 - 01/2019
2	Neurodegenerative Diseases (Neurodegenerative Disease) 05/2021 - 01/2014
2	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 01/2019 - 10/2016
1	Treatment-Resistant Schizophrenia 12/2023
1	Dementia (Dementias) 10/2023
1	Neurobehavioral Manifestations 09/2023
1	Schizophrenia (Dementia Praecox) 09/2023
1	Ischemia 01/2023
1	Brain Ischemia (Cerebral Ischemia) 01/2023
1	Intracranial Vasospasm 01/2023
1	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 01/2023
1	Ischemic Stroke 01/2022
1	Brain Injuries (Brain Injury) 01/2022
1	Stroke (Strokes) 01/2022
1	Acute Pain 01/2022
1	Chronic Fatigue Syndrome (Myalgic Encephalomyelitis) 11/2021
1	Parkinsonian Disorders (Parkinsonism) 05/2021
1	Social Phobia 01/2021
1	Autism Spectrum Disorder 01/2021
1	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2019
1	Anxiety Disorders (Anxiety Disorder) 01/2019
1	Nervous System Diseases (Neurological Disorders) 01/2019
1	Hyperalgesia 01/2019

Drug/Important Bio-Agent (IBA)

14	Tryptophan (L-Tryptophan)FDA Link 01/2024 - 12/2004
11	MelatoninIBA 12/2023 - 03/2007
10	KynurenineIBA 01/2024 - 12/2019
8	Serotonin (5 Hydroxytryptamine)IBA 04/2023 - 08/2006
5	Neurotransmitter Agents (Neurotransmitter)IBA 05/2019 - 01/2014
5	MT2 Melatonin ReceptorIBA 01/2019 - 01/2014
4	Antidepressive Agents (Antidepressants)IBA 03/2022 - 01/2018
4	Analgesics (Analgesic Drugs)IBA 01/2022 - 02/2015
3	Quetiapine Fumarate (Seroquel)FDA Link 11/2023 - 01/2014
3	Antipsychotic Agents (Antipsychotics)IBA 03/2022 - 11/2016
3	N- (2- ((3- bromophenyl)- (4- fluorophenyl)amino)ethyl)acetamideIBA 01/2018 - 02/2015
3	5-Hydroxytryptophan (5 Hydroxytryptophan)IBA 10/2016 - 03/2007
2	MT1 Melatonin ReceptorIBA 05/2024 - 01/2019
2	Biomarkers (Surrogate Marker)IBA 01/2024 - 11/2021
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 10/2023 - 10/2020
2	Glutamic Acid (Glutamate)FDA Link 01/2023 - 01/2016
2	Valproic Acid (Depakote)FDA LinkGeneric 04/2022 - 01/2016
2	CytokinesIBA 01/2022 - 11/2021
2	Cocaine (Cocaine HCl)IBA 11/2021 - 01/2019
2	Proteins (Proteins, Gene)FDA Link 05/2021 - 01/2018
2	Dopamine (Intropin)FDA LinkGeneric 05/2021 - 01/2016
2	LigandsIBA 01/2019 - 02/2015
2	Olanzapine (Zyprexa)FDA Link 01/2018 - 01/2014
2	Gabapentin (Neurontin)FDA LinkGeneric 01/2018 - 02/2015
2	N- (2- ((3- methoxyphenyl)phenylamino)ethyl)acetamideIBA 01/2018 - 10/2015
2	EnzymesIBA 01/2017 - 12/2004
2	acetamideIBA 10/2015 - 02/2015
2	Hypnotics and Sedatives (Sedatives)IBA 01/2014 - 12/2011
1	Quinolinic AcidIBA 04/2023
1	3-hydroxykynurenineIBA 04/2023
1	Kynurenic Acid (Kynurenate)IBA 04/2023
1	Lamotrigine (Lamictal)FDA LinkGeneric 04/2022
1	LithiumIBA 04/2022
1	Coloring Agents (Dyes)IBA 01/2022
1	Neuroprotective AgentsIBA 01/2022
1	Biological FactorsIBA 01/2022
1	Therapeutic UsesIBA 01/2022
1	Rose BengalIBA 01/2022
1	Fatty Acid-Binding ProteinsIBA 11/2021
1	A-factor (Streptomyces)IBA 11/2021
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2021
1	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA 01/2021
1	Hallucinogens (Psychedelics)IBA 01/2021
1	Dizocilpine Maleate (Dizocilpine)IBA 10/2020
1	Trace Elements (Biometals)IBA 01/2019
1	ZincIBA 01/2019
1	CadmiumIBA 01/2019
1	CannabidiolIBA 01/2019
1	CopperIBA 01/2019
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2019
1	5-HT1A Serotonin ReceptorIBA 01/2019
1	palmidrolIBA 01/2019
1	BenzodiazepinesIBA 01/2018
1	Pregabalin (Lyrica)FDA Link 01/2018
1	Messenger RNA (mRNA)IBA 01/2018
1	Zolpidem (Ambien)FDA LinkGeneric 01/2018
1	suvorexantIBA 01/2018

Therapy/Procedure

3	Therapeutics 01/2022 - 01/2011
2	Drug Therapy (Chemotherapy) 12/2023 - 01/2018
2	Precision Medicine 04/2022 - 11/2021
1	Analgesia 01/2019